Sestrin2 promotes LKB1‐mediated AMPK activation in the ischemic heart
نویسندگان
چکیده
منابع مشابه
Activation of AMPK - and -isoform complexes in the intact ischemic rat heart
Ji Li, David L. Coven, Edward J. Miller, Xiaoyue Hu, Martin E. Young, David Carling, Albert J. Sinusas, and Lawrence H. Young Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut; Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas; and Cellular Stress Group, Imperia...
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AMP-activated protein kinase (AMPK) is emerging as an important signaling protein during myocardial ischemia. AMPK is a heterotrimeric complex containing an alpha catalytic subunit and beta and gamma regulatory subunits. Phosphorylation of Thr172 in the activation loop of the alpha subunit by upstream AMPK kinase(s) (AMPKK) is a critical determinant of AMPK activity. However, the mechanisms reg...
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Angiogenesis plays critical roles in development, tumor growth and metastasis. Flufenamic acid (FFA) is an anti-inflammatory agent known to alter ion fluxes across the plasma membrane. Its role in angiogenesis has not been fully addressed to date. Here, we report that FFA treatment promotes angiogenesis both in vitro and in vivo. Applying FFA for 12 h promoted tube formation of human umbilical ...
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There has been a longstanding interest in the development of metabolic modulations to improve the outcome of myocardial ischemia. The glucose-insulinpotassium (GIK) regimen presents the classic example of such a quest. For more than four decades since GIK was first described, substantial evidence from animal research and small size clinical studies has supported the efficacy of GIK treatment fo...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.14-258814